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Nanoparticles for multimodal in vivo imaging in nanomedicine

Authors Key J, Leary JF

Received 29 August 2013

Accepted for publication 9 October 2013

Published 29 January 2014 Volume 2014:9(1) Pages 711—726


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5

Jaehong Key,1–3 James F Leary1–4

1Weldon School of Biomedical Engineering, 2Birck Nanotechnology Center, 3Bindley Bioscience Center, 4College of Veterinary Medicine, Purdue University, West Lafayette, IN, USA

Abstract: While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously provide diagnostic information by a variety of in vivo imaging methods. These diagnostic capabilities make use of specific properties of nanoparticle core materials. Near-infrared fluorescent probes provide optical detection of cells targeted by real-time nanoparticle-distribution studies within the organ compartments of live, anesthetized animals. By combining different imaging modalities, we can start with deep-body imaging by magnetic resonance imaging or computed tomography, and by using optical imaging, get down to the resolution required for real-time fluorescence-guided surgery.

Keywords: nanomedicine, nanoparticles, multimodal imaging, CT, MRI, NIRF, PET, cancer

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