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Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives

Authors Edis Z, Wang J, Waqas MK, Ijaz M, Ijaz M

Received 6 November 2020

Accepted for publication 23 December 2020

Published 17 February 2021 Volume 2021:16 Pages 1313—1330

DOI https://doi.org/10.2147/IJN.S289443

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Thomas J. Webster


Zehra Edis,1,2,* Junli Wang,3,* Muhammad Khurram Waqas,4 Muhammad Ijaz,5 Munazza Ijaz6

1Department of Pharmaceutical Sciences,College of Pharmacy and Health Sciences, Ajman University, Ajman, United Arab Emirates; 2Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, United Arab Emirates; 3Laboratory of Reproduction and Genetics, Affiliated Hospital of Youjiang Medical College for Nationalities, Baise, Guangxi, People’s Republic of China; 4Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan; 5Department of Pharmacy, COMSATS University Islamabad, Lahore Campus, Lahore, Pakistan; 6Institute of Molecular Biology and Biotechnology, The University of Lahore, Defense Road Campus, Lahore, Pakistan

*These authors contributed equally to this work

Correspondence: Munazza Ijaz
Institute of Molecular Biology and Biotechnology, The University of Lahore, Defense Road Campus, Lahore, 54000, Pakistan
Email munazza3murtaza@gmail.com

Abstract: Nanotechnology has been actively integrated as drug carriers over the last few years to treat various cancers. The main hurdle in the clinical management of cancer is the development of multidrug resistance against chemotherapeutic agents. To overcome the limitations of chemotherapy, the researchers have been developing technological advances for significant progress in the oncotherapy by enabling the delivery of chemotherapeutic agents at increased drug content levels to the targeted spots. Several nano-drug delivery systems designed for tumor-targeting are evaluated in preclinical and clinical trials and showed promising outcomes in cancerous tumors’ clinical management. This review describes nanocarrier’s importance in managing different types of cancers and emphasizing nanocarriers for drug delivery and cancer nanotherapeutics. It also highlights the recent advances in nanocarriers-based delivery systems, including polymeric nanocarriers, micelles, nanotubes, dendrimers, magnetic nanoparticles, solid lipid nanoparticles, and quantum dots (QDs). The nanocarrier-based composites are discussed in terms of their structure, characteristics, and therapeutic applications in oncology. To conclude, the challenges and future exploration opportunities of nanocarriers in chemotherapeutics are also presented.

Keywords: nanomaterials, anticancer agents, recent advances, multidrug resistance, chemotherapy

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