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Molecular mechanisms of hyperglycemia and cardiovascular-related events in critically ill patients: rationale for the clinical benefits of insulin therapy

Authors Ellahham

Published 12 December 2010 Volume 2010:2 Pages 281—288

DOI https://doi.org/10.2147/CLEP.S15162

Review by Single-blind

Peer reviewer comments 4


Samer Ellahham
Paragon Cardiovascular Foundation, Falls Church, VA, USA

Abstract: Newly recognized hyperglycemia frequently occurs with acute medical illness, especially among patients with cardiovascular disease (CVD). Hyperglycemia has been linked to increased morbidity and mortality in critically ill patients, especially when it is newly recognized. Increased rates of reinfarction, rehospitalization, major cardiovascular events, and death in CVD patients have also been found. An expanding body of literature describes the benefits of normalizing hyperglycemia with insulin therapy in hospitalized patients. This article reviews several underlying mechanisms thought to be responsible for the association between hyperglycemia and poor outcomes in critically ill patients and those with cardiovascular events, as well as the biologic rationale for the benefits of insulin therapy in these patients.

Keywords: hyperglycemia, diabetes, cardiovascular disease, critical illness, insulin

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