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Molecular and structural bases for postsynaptic signal processing: interaction between postsynaptic density and postsynaptic membrane rafts

Authors Suzuki T, Yao WD

Received 31 August 2013

Accepted for publication 30 September 2013

Published 9 December 2013 Volume 2014:2 Pages 1—14

DOI https://doi.org/10.2147/JN.S49206

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Tatsuo Suzuki,1 Wei-Dong Yao2

1Department of Neuroplasticity, Shinshu University Graduate School of Medicine, Matsumoto, Japan; 2Department of Psychiatry, Beth Israel Deaconess Medical Center, and Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, MA, USA

Abstract: Postsynaptic membrane rafts (or lipid rafts) (PSRs), together with the postsynaptic density (PSD), are believed to be major sites important for postsynaptic signaling, function, and plasticity. Although the PSD has received much attention and is extensively investigated, PSR roles and their relationship with PSDs are poorly understood. Our recent work has identified PSD–PSR complexes from synaptic membranes of the rat brain and demonstrated specific interactions between them in vitro. Here, we review recent progress in this field, focusing on the molecular identities of the PSR, its biochemical purification, and its potential roles in postsynaptic signaling, function, and plasticity via cross talk with the PSD. We propose that the PSR and PSD are two major postsynaptic signaling domains that interact physiologically, and that PSRs are indispensable to PSD functions. Roles of PSRs in synaptogenesis, growth, and maturation of developing PSDs, and support and regulation of functions and plasticity of mature PSDs are discussed.

Keywords: postsynaptic density, postsynaptic membrane raft, synaptic plasticity, synaptogenesis, synaptic structure

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