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Modeling human influenza infection in the laboratory

Authors Radigan K, Misharin A, Chi M, Budinger S

Received 19 March 2015

Accepted for publication 14 May 2015

Published 31 August 2015 Volume 2015:8 Pages 311—320

DOI https://doi.org/10.2147/IDR.S58551

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 4

Editor who approved publication: Professor Suresh Antony

Kathryn A Radigan,1 Alexander V Misharin,2 Monica Chi,1 GR Scott Budinger1

1Division of Pulmonary and Critical Care Medicine, 2Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

Abstract: Influenza is the leading cause of death from an infectious cause. Because of its clinical importance, many investigators use animal models to understand the biologic mechanisms of influenza A virus replication, the immune response to the virus, and the efficacy of novel therapies. This review will focus on the biosafety, biosecurity, and ethical concerns that must be considered in pursuing influenza research, in addition to focusing on the two animal models – mice and ferrets – most frequently used by researchers as models of human influenza infection.

Keywords: mice, ferret, influenza, animal model, biosafety

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