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Migraine and restless legs syndrome: current perspectives

Authors Ferreira K, Dach F, Eckeli A, Speciali JG

Received 3 September 2015

Accepted for publication 14 October 2015

Published 15 December 2015 Volume 2015:5 Pages 39—44

DOI https://doi.org/10.2147/JPRLS.S85484

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Anamitra Ghosh

Peer reviewer comments 5

Editor who approved publication: Dr Peter Hedera


Karen dos Santos Ferreira, Fabíola Dach, Alan L Eckeli, José Geraldo Speciali

Department of Neurosciences and Behavioral Sciences, Division of Neurology, University Hospital, Medical School of Ribeirao Preto, University of São Paulo, São Paulo, Brazil

Abstract: The relationship between migraine and restless legs syndrome (RLS) has been described in the literature for some years, based on clinical findings and pathophysiological considerations. There are some possible factors relating migraine and RLS. Both are diseases involving the central nervous system, the two diseases seem to share a dopaminergic mechanism, and it is also believed that they may share a genetic origin. At present, doctors who work with these two diseases should be encouraged not to simply investigate the simultaneous presence of both, but should also apply a treatment better adapted to this possibility. Research should be directed at some still unanswered questions for a better understanding of the association between migraine and RLS.

Keywords: migraine, restless legs syndrome, physiopathology, comorbidities

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