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Metabolic syndrome in adults with a history of juvenile arthritis

Authors Sule S, Fontaine K

Received 16 November 2017

Accepted for publication 21 March 2018

Published 6 June 2018 Volume 2018:10 Pages 67—72

DOI https://doi.org/10.2147/OARRR.S157229

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Lucy Goodman

Peer reviewer comments 3

Editor who approved publication: Professor Chuan-Ju Liu


Sangeeta Sule,1 Kevin Fontaine2

1Department of Pediatric, Pediatric Rheumatology, Johns Hopkins University, Baltimore, MD, USA; 2Department of Health Behavior, University of Alabama at Birmingham, Birmingham, AL, USA

Objective: The objective of this study was to determine the risk of obesity and metabolic syndrome in adults with a history of juvenile arthritis (JA).
Methods: Using the National Health and Nutrition Examination Survey (NHANES), we compared the characteristics of respondents with arthritis (JA vs rheumatoid arthritis [RA]) to those of the control group without arthritis. We used logistic regression analyses, controlling for age, race, and gender, to determine the ORs for metabolic syndrome.
Results: Obesity was increased in the JA group with 67% respondents having body mass index ≥30 kg/m2 vs 55% respondents in the no arthritis cohort (p=0.004). In unadjusted analyses, there was increased odds of metabolic syndrome in JA (OR 6.2, p=0.001) and RA groups compared to those without arthritis (OR 7.7, p=0.001). After adjusting for age, gender, and race, the odds of metabolic syndrome remained increased in JA (OR 5.2, p=0.001) and RA (OR 3.2, p=0.001) groups.
Conclusion: Adults with a history of JA have a significantly increased risk of metabolic syndrome compared to those without arthritis. These findings are important because metabolic syndrome has been associated with an increased risk of cardiovascular disease and death in other populations.

Keywords: juvenile arthritis, outcomes research, cardiovascular disease

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