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Mesoporous silica nanoparticles for stimuli-responsive controlled drug delivery: advances, challenges, and outlook

Authors Song Y, Li Y, Xu Q, Liu Z

Received 18 July 2016

Accepted for publication 3 August 2016

Published 20 December 2016 Volume 2017:12 Pages 87—110

DOI https://doi.org/10.2147/IJN.S117495

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Lei Yang


Yuanhui Song, Yihong Li, Qien Xu, Zhe Liu

Wenzhou Institute of Biomaterials and Engineering (WIBE), Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China

Abstract:
With the development of nanotechnology, the application of nanomaterials in the field of drug delivery has attracted much attention in the past decades. Mesoporous silica nanoparticles as promising drug nanocarriers have become a new area of interest in recent years due to their unique properties and capabilities to efficiently entrap cargo molecules. This review describes the latest advances on the application of mesoporous silica nanoparticles in drug delivery. In particular, we focus on the stimuli-responsive controlled release systems that are able to respond to intracellular environmental changes, such as pH, ATP, GSH, enzyme, glucose, and H2O2. Moreover, drug delivery induced by exogenous stimuli including temperature, light, magnetic field, ultrasound, and electricity is also summarized. These advanced technologies demonstrate current challenges, and provide a bright future for precision diagnosis and treatment.

Keywords:
mesoporous silica nanoparticle, drug delivery system, controlled release, stimuli-responsive, chemotherapy

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