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Memantine induces manic episode in a 73-year-old patient with vascular neurocognitive disorder: a case report

Authors Duan JF, Lao CM, Chen JK, Pan F, Zhang CL, Xu WJ, Zhou WH, Hu JB, Shang DS, Huang ML, Xu Y

Received 25 December 2017

Accepted for publication 20 March 2018

Published 30 May 2018 Volume 2018:14 Pages 1395—1398


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Professor Wai Kwong Tang

Jinfeng Duan,1,2 Chengming Lao,3,4 Jingkai Chen,1,2 Fen Pan,1,2 Chenlin Zhang,3 Weijuan Xu,1,2 Weihua Zhou,1,2 Jianbo Hu,1,2 Desheng Shang,1 Manli Huang,1,2 Yi Xu1,2

1Department of Psychiatry, First Affiliated Hospital, College of Medicine, Zhejiang University, The Key Laboratory of Mental Disorder’s Management of Zhejiang Province, Hangzhou, People’s Republic of China; 2Brain Research Institute of Zhejiang University, Hangzhou, People’s Republic of China; 3College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China; 4Yiwu Mental Health Center, Yiwu, People’s Republic of China

Memantine, an N-methyl-D-aspartate receptor antagonist, is a well-established treatment option for moderate-to-severe cognitive impairment related to Alzheimer disease. Recently, growing evidence has indicated memantine might also be effective in treatment of affective disorders. The common drug-induced adverse events of memantine include confusion, dizziness, drowsiness, headache, insomnia, and agitation. Herein, we presented a case of a 73-year-old female patient with vascular neurocognitive disorder, who developed a manic episode after taking memantine.

Keywords: memantine, depression, dementia, manic episode

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