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Matrix metalloproteinases in pancreatitis: current insights

Authors Sri Manjari K, Nallari P, Venkateshwari A

Received 21 September 2016

Accepted for publication 22 November 2016

Published 31 January 2017 Volume 2017:4 Pages 15—23

DOI https://doi.org/10.2147/MNM.S105774

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Yoshifumi Itoh


Kavutharapu Sri Manjari, Pratibha Nallari, Ananthapur Venkateshwari

Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad, India

Abstract: Matrix metalloproteinases (MMPs) belong to a family of zinc-dependent endopeptidases belonging to the metzincin superfamily of metalloproteinases. MMPs can degrade most of the constituents of the extracellular matrix, basement membrane, and inflammatory mediators. Most of the MMPs are not expressed in normal tissue, but their expression and activity increase dramatically during wound healing as a result of a change in matrix composition, inflammation, and repair. Pancreatitis refers to inflammation of the pancreas resulting in an imbalance in its normal function. MMPs are involved in events like chronic inflammation, fibrosis, and resolution of the disease. There have been substantial advances in understanding the pathogenesis of acute and chronic pancreatitis, because of the recent scientific progress in the underlying genetic, cellular, and molecular pathophysiology. This study will provide an evidence-based review of the importance of MMPs in pancreatitis.

Keywords: pancreatic stellate cells, acinar cells, extracellular matrix, inflammation, matrix remodeling

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