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Marked radiographic response of a HER-2-overexpressing biliary cancer to trastuzumab

Authors Sorscher S

Received 28 September 2013

Accepted for publication 10 November 2013

Published 11 December 2013 Volume 2014:6 Pages 1—3

DOI https://doi.org/10.2147/CMAR.S55091

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 6


Steven Sorscher

Washington University School of Medicine, Department of Oncology, St Louis, MO, USA

Abstract: Trastuzumab is a monoclonal antibody targeting HER-2. HER-2 overexpression has been described in gallbladder cancer and in cholangiocarcinoma. This report describes the first case of a patient with HER-2 overexpressing metastatic gallbladder adenocarcinoma and responding radiographically and biochemically to trastuzumab alone.

Keywords: metastatic gallbladder adenocarcinoma, HER-2 overexpression, trastuzumab

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