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Management of relapsed/refractory marginal zone lymphoma: focus on ibrutinib

Authors Denlinger NM, Epperla N, William BM

Received 10 October 2017

Accepted for publication 2 February 2018

Published 27 March 2018 Volume 2018:10 Pages 615—624

DOI https://doi.org/10.2147/CMAR.S133291

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Leylah Drusbosky


Nathan M Denlinger, Narendranath Epperla, Basem M William

Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center (OSUCCC-James), The Ohio State University, Columbus, OH, USA

Abstract: Marginal zone lymphomas (MZLs) consist of a diverse family of malignancies, which are derived from B-cells. The disease subtypes are recognized extranodal, nodal, and splenic MZLs. The disease characteristics, clinical course, and treatment vary considerably based on the site of involvement. In 2017, the US Food and Drug Administration approved ibrutinib, a first in class Bruton’s tyrosine kinase inhibitor that revolutionized the care of chronic lymphocytic leukemia patients; for, the treatment of relapsed/refractory MZL based on pivotal open-label Phase II trial demonstrated an overall response rate of 48%, with a complete response rate of 3%, median progression-free survival of 14.2 months, and median overall survival not yet reached at a median follow-up of 19.4 months. In this review, we aim to summarize the current conundrums in the management of MZL and the evolving role of ibrutinib in the treatment of MZL.

Keywords: non-Hodgkin’s lymphoma, marginal zone, ibrutinib

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