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Lymph Node Yield Following Packet Submission After Isolation By Surgeon During Gastrectomy

Authors Wang P, Zhang K, Xi H, Liang W, Xie T, Gao Y, Wei B, Chen L

Received 5 April 2019

Accepted for publication 20 October 2019

Published 19 November 2019 Volume 2019:11 Pages 9871—9881

DOI https://doi.org/10.2147/CMAR.S211218

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Alexandra R. Fernandes


Pengpeng Wang,1,2 Kecheng Zhang,2 Hongqing Xi,2 Wenquan Liang,2 Tianyu Xie,1,2 Yunhe Gao,2 Bo Wei,2 Lin Chen1,2

1School of Medicine, Nankai University, Tianjin 300071, People’s Republic of China; 2Department of General Surgery, Chinese People’s Liberation Army General Hospital, Beijing 100853, People’s Republic of China

Correspondence: Bo Wei; Lin Chen
Department of General Surgery, Chinese People’s Liberation Army General Hospital, Fuxing Road 28#, Haidian District, Beijing 100853, People’s Republic of China
Email weibo@vip.163.com; chenlin@301hospital.com.cn

Purpose: To compare the lymph node yields of lymph node packet submission (PS), packet submission after isolation by surgeons (PSI), and en bloc lymph node submission (EBS) after gastrectomy.
Methods: We conducted a prospective study including 118 gastric cancer patients who underwent gastrectomy between June 2016 and August 2016. We also retrospectively reviewed 607 patients who underwent gastrectomy from May 2015 to May 2016. Following gastrectomy, lymph node specimens were either submitted en bloc (EBS group), divided into packets with accompanying adipose tissue according to the lymph node stations (PS group), or isolated individually based on the surgeon’s visualization and palpation before submission to the Pathology Department (PSI group).
Results: The average lymph node yield was significantly higher in the PSI compared with the PS group in the prospective study (46.5±19.4 vs 31.8±11.1), and significantly higher in the PS compared with the EBS group in the retrospective study (31.5±12.6 vs 23.9±8.9) (both P<0.001). There was no significant difference in positive lymph node yields in either of these comparisons (prospective study, P=0.581; retrospective study, P=0.489). The survival curve indicated no significant difference between the PS and PSI groups (log rank P=0.957); however, these three groups share different lymph node ratio (LNR).
Conclusion: PSI could yield more lymph nodes than PS or EBS with a lower LNR at pathological examination. However, the difference in lymph nodes harvested had no impact on survival, which may need further investigation.

Keywords: lymph node retrieval, lymph node, gastric cancer, gastrectomy, cancer staging

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