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Long noncoding RNA SPRY4-IT1 promotes malignant development of colorectal cancer by targeting epithelial–mesenchymal transition

Authors Cao D, Ding Q, Yu W, Gao M, Wang Y

Received 2 May 2016

Accepted for publication 21 June 2016

Published 30 August 2016 Volume 2016:9 Pages 5417—5425

DOI https://doi.org/10.2147/OTT.S111794

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Manfred Beleut

Peer reviewer comments 2

Editor who approved publication: Dr William Cho


Dong Cao,1 Qiong Ding,1 Wubin Yu,1 Ming Gao,1 Yilian Wang2

1Department of General Surgery, The People’s Hospital of Putuo, Zhoushan, 2Department of Cardiology, The Second People’s Hospital of Lianyungang, Xinpu, People’s Republic of China

Abstract: The clinical significance and biological functions of long noncoding RNA SPRY4 intronic transcript 1 (SPRY4-IT1) in colorectal cancer (CRC) remain largely unclear. Herein, we are the first to report that the SPRY4-IT1 was significantly upregulated in CRC tissues, serum, and cells. Higher SPRY4-IT1 expression was markedly associated with advanced Tumor Node Metastasis (TNM) stage in a cohort of 84 CRC patients. Multivariate analyses indicated that SPRY4-IT1 expression could be useful as an independent predictor for overall survival. Further in vitro experiments revealed that knockdown of SPRY4-IT1 inhibited the proliferation, migration, and invasion of CRC cells and induced cell cycle arrestment. Moreover, we confirmed that the expression of epithelial–mesenchymal transition-related genes was modulated through alteration of SPRY4-IT1 expression. These results suggest that SPRY4-IT1, as an oncogenic regulator, may serve as a candidate prognostic marker and potential target for CRC therapies.

Keywords: long noncoding RNA, SPRY4-IT1, colorectal cancer, survival

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