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Long Non-Coding Small Nucleolar RNA Host Genes (SNHGs) in Endocrine-Related Cancers

Authors Qin Y, Sun W, Wang Z, Dong W, He L, Zhang T, Zhang H

Received 11 June 2020

Accepted for publication 17 July 2020

Published 5 August 2020 Volume 2020:13 Pages 7699—7717


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Cho

Yuan Qin ,* Wei Sun ,* Zhihong Wang, Wenwu Dong, Liang He, Ting Zhang, Hao Zhang

Department of Thyroid Surgery, The First Hospital of China Medical University, Shenyang 110001, Liaoning Province, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Hao Zhang
Department of Thyroid Surgery, The First Hospital of China Medical University, 155 Nanjing Bei Street, Shenyang, Liaoning 110001, People’s Republic of China

Abstract: Long non-coding RNAs (lncRNAs) are emerging regulators of a diverse range of biological processes through various mechanisms. Genome-wide association studies of tumor samples have identified several lncRNAs, which act as either oncogenes or tumor suppressors in various types of cancers. Small nucleolar RNAs (snoRNAs) are predominantly found in the nucleolus and function as guide RNAs for the processing of transcription. As the host genes of snoRNAs, lncRNA small nucleolar RNA host genes (SNHGs) have been shown to be abnormally expressed in multiple cancers and can participate in cell proliferation, tumor progression, metastasis, and chemoresistance. Here, we review the biological functions and emerging mechanisms of SNHGs involved in the development and progression of endocrine-related cancers including thyroid cancer, breast cancer, pancreatic cancer, ovarian cancer and prostate cancer.

Keywords: endocrine, cancers, lncRNA, SNHG

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