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Liposomal formulation of vitamin A for the potential treatment of osteoporosis

Authors Sachaniya J, Savaliya R, Goyal R, Singh S

Received 14 October 2016

Accepted for publication 21 November 2016

Published 15 March 2018 Volume 2018:13(T-NANO 2014 Abstracts) Pages 51—53


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Lei Yang

Jainy Sachaniya, Reema Savaliya, Ramesh Goyal, Sanjay Singh

Institute of Life Sciences, School of Science and Technology, Ahmedabad University, Ahmedabad, Gujarat, India

Abstract: Vitamin A targeting to bones is a suitable treatment for osteoporosis. In this study, we have developed vitamin A-encapsulated liposomes that can be useful to deliver vitamin A to the bones in a selective manner. This liposomal formulation of vitamin A has been found to be stable for >6 months as no significant change in size and charge occurred. Vitamin A liposomes-induced cell proliferation in SaOS-2 (human osteosarcoma cell line) and release kinetics study concluded that the liposomal formulation of vitamin A gives a controlled release of vitamin A in comparison to the free vitamin. The MTT assay showed the proliferation of SaOS-2 cells after their treatment with vitamin A liposomes.

Keywords: SaOS-2, nanoliposomes, osteoporosis

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