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Levodopa-responsive depression associated with corticobasal degeneration: a case report

Authors Tarakita N, Nishijima H, Yasui-Furukori N

Received 10 March 2017

Accepted for publication 31 March 2017

Published 18 April 2017 Volume 2017:13 Pages 1107—1110


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Taro Kishi

Natsumi Tarakita,1 Haruo Nishijima,2 Norio Yasui-Furukori1

1Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, 2Department of Neurology, Aomori Prefectural Central Hospital, Aomori, Japan

Abstract: A 60-year-old female was treated for depression with the antidepressant paroxetine for 13 years. The patient had experienced clumsiness and mild rigidity in the left hand, and had agraphia and mild subjective memory complaints for 3 years prior to admission in our hospital. She experienced exacerbated depression that included worsened depressive mood, lowered motivation, and suicidal ideation without precipitating stressful life events for 2 years prior to admission, and although she had continued taking the antidepressant, these symptoms were not ameliorated by increasing the dose of paroxetine. Following the development of myoclonus and pain in her left arm, we performed magnetic resonance imaging of her head, that revealed diffuse atrophy and right parietal lobe atrophy. The patient was ultimately diagnosed with corticobasal degeneration (CBD). Her left arm myoclonus and depression improved following levodopa administration. Therefore, we concluded that the recurrent depression may have been induced by CBD.

Keywords: corticobasal degeneration, depression, cognitive decline

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