Back to Journals » Cancer Management and Research » Volume 11

Meta-analysis of the prognostic role of HE4 expression in cancer patients: clinical insights into interpretation of clinical outcomes

Authors Jayaraj R, Kumarasamy C

Received 14 December 2018

Accepted for publication 6 January 2019

Published 21 February 2019 Volume 2019:11 Pages 1791—1794


Checked for plagiarism Yes

Editor who approved publication: Dr Antonella D'Anneo

Rama Jayaraj,1 Chellan Kumarasamy2

1College of Health and Human Sciences, Charles Darwin University, Casuarina, NT, Australia; 2University of Adelaide, North Terrace Campus, Adelaide, SA, Australia

An article titled, “Prognostic values of HE4 expression in patients with cancer: a metaanalysis”, was recently published in the journal, Cancer Management and Research, detailing a study conducted by Dai et al.1 This study aims to validate and estimate the effectiveness of HE4 as a prognostic marker in cancer. We commend the authors for the study’s focus on all types of cancers, as well as the associated subgroup analysis detailing the results for individual cancer types and population groups. This study is valuable as a guidepost for informing future research on HE4 as a prognostic biomarker to predict the cancer patients’ clinical outcomes. However, there are a few points that require to be addressed regarding the study conducted.

Authors’ reply

Cong Dai,1 Yi Zheng,1 Tian Tian,1 Zhijun Dai,1 Jun Lyu2

1Department of Oncology, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710004, China; 2Jun Lyu, Clinical Research Center, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China

We thank Dr Rama Jayaraj and Chellan Kumarasamy for their interest and comments. They came up with several valuable points that improved our meta-analysis.1

Read the original paper.

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]