Back to Journals » The Application of Clinical Genetics » Volume 12

Ketogenic diet in ATAD3A mutation carriers may not improve cerebellar atrophy but some clinical features [Letter]

Authors Finsterer J

Received 30 June 2019

Accepted for publication 11 July 2019

Published 5 August 2019 Volume 2019:12 Pages 161—162


Checked for plagiarism Yes

Editor who approved publication: Prof. Dr. Martin H. Maurer

Josef Finsterer

Krankenanstalt Rudolfstiftung, Messerli Institute, Vienna, Austria

With interest I read the article by Madhoun et al about a 4.5-year-old female with multisystem mitochondrial disorder (MID) due to the variant c.251T>C in the ATAD3A gene.1 The patient was reported to have profited from the ketogenic diet (KD) by slowing the progression of cerebellar atrophy, and improving vitality, interaction, moaning, carrying, tremor, and weakness. I have the following comments and concerns.

View the original paper by Madhoun and colleagues.

A Response to Letter has been published for this article.

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]