Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions? Observations and introspection of the bioanalysis
Disha Thakkar,1 Ranjeet Prasad Dash2,3
1Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research-Ahmedabad, Gandhinagar, Gujarat, India; 2Drug Metabolism and Pharmacokinetics, Johns Hopkins Drug Discovery Program, Johns Hopkins University, 3Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
The topic of polymorphism in drug metabolizing enzymes and drug transporters with their impact on pharmacotherapy is of great interest. The clinical relevance depends on the vectorial movement, the therapeutic index of the substrates and inherent interindividual variability.1 With respect to the variability, various polymorphisms associated with the drug transporters have been reported that led to the alteration in the pharmacokinetic and pharmacodynamic profile of the drugs.2 Many preclinical and clinical studies have provided the evidence for the application of genetic information for the development of individualized therapies.3
Min Soo Park1,2
1Department of Clinical Pharmacology, Severance Hospital, 2Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea
First of all, we would like to thank Thakkar and Dash for their interest in our paper “Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions?” Regarding their concerns about the sample processing of rosuvastatin and N-desmethyl rosuvastatin, they seem to have misunderstood because detailed contents were missed.
View the original paper by Kim CO and colleagues.
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