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Kleine-Levin syndrome: a review

Authors Miglis M, Guilleminault C

Received 28 September 2013

Accepted for publication 13 November 2013

Published 20 January 2014 Volume 2014:6 Pages 19—26

DOI https://doi.org/10.2147/NSS.S44750

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 5


Mitchell G Miglis, Christian Guilleminault

Stanford University Sleep Medicine Division, Stanford Outpatient Medical Center, Redwood City, CA, USA

Abstract: Kleine-Levin syndrome is a recurrent hypersomnia associated with symptoms of hyperphagia, hypersexuality, and cognitive impairment. This article reviews the current available research and describes common clinical symptoms, differential diagnosis, and acceptable workup and treatment. Although deficits have traditionally been thought to resolve between episodes, functional imaging studies and long-term neuropsychological testing in select patients have recently challenged this notion. This may suggest that Kleine-Levin syndrome is not as benign as previously considered.

Keywords: Kleine-Levin syndrome, hypersomnia, adolescent sleep disorder, hypersexuality


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