Back to Journals » Journal of Pain Research » Volume 11

Is preoperative hypocholesterolemia a risk factor for severe postoperative pain? Analysis of 1,944 patients after laparoscopic colorectal cancer surgery

Authors Oh TK, Kang SB, Song IA, Hwang JW, Do SH, Kim JH, Oh AY

Received 30 September 2017

Accepted for publication 3 April 2018

Published 1 June 2018 Volume 2018:11 Pages 1057—1065


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Katherine Hanlon

Tak Kyu Oh,1 Sung-Bum Kang,2 In-Ae Song,1 Jung-Won Hwang,1 Sang-Hwan Do,1 Jin Hee Kim,1 Ah-Young Oh1

1Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 2Department of Surgery, Seoul National University Bundang Hospital, Seoul, South Korea

Purpose: This study aimed to identify the effect of preoperative serum total cholesterol on postoperative pain outcome in patients who had undergone laparoscopic colorectal cancer surgery.
Methods: We retrospectively reviewed the medical records of patients diagnosed with colorectal cancer who had undergone laparoscopic colorectal surgery from January 1, 2011, to June 30, 2017, to identify the relationship of total cholesterol levels within a month prior to surgery with the numeric rating scale (NRS) scores and total opioid consumption on postoperative days (PODs) 0–2.
Results: We included 1,944 patients. No significant correlations were observed between total cholesterol and the NRS (POD 0), NRS (POD 1), and oral morphine equivalents (PODs 0–2) (P>0.05). There was no significant difference between the low (<160 mg/dL), medium (160–199 mg/dL), and high (≥200 mg/dL) groups in NRS scores on PODs 0, 1, or 2 (P>0.05). Furthermore, there was no significant association in multivariate linear regression analysis for postoperative opioid consumption according to preoperative serum total cholesterol level (coefficient 0.08, 95% CI –0.01 to 0.18, P=0.81).
Conclusion: This study showed that there was no meaningful association between preoperative total cholesterol level and postoperative pain outcome after laparoscopic colorectal cancer surgery.

Keywords: cholesterol, analgesia, colon, rectum, laparoscopy

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]