Is acupuncture effective in the treatment of pain in endometriosis?
Authors Lund I, Lundeberg T
Received 20 August 2015
Accepted for publication 15 October 2015
Published 24 March 2016 Volume 2016:9 Pages 157—165
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Kerui Gong
Peer reviewer comments 2
Editor who approved publication: Dr Michael Schatman
Iréne Lund,1 Thomas Lundeberg2
1Department of Physiology and Pharmacology, Karolinska Institutet, 2Rehabilitation Medicine University Clinic Stockholm, Danderyds Hospital AB, Stockholm, Sweden
Introduction: Endometriosis is a multifactorial, estrogen-dependent, inflammatory gynecological condition – often with long-lasting visceral pelvic pain of different origin, and infertility among women. Current management options for patients’ are often inadequate, with side effects for many for whom acupuncture techniques could be an alternative. Earlier studies have discussed the efficacy of acupuncture, but not its methodological aspects.
Objectives: To summarize the documented clinical effects of acupuncture on rated visceral pelvic endometriosis-related pain, and associated variables among individuals, within and between studied groups, and to discuss the methodological treatment aspects.
Methods: Published full text clinical studies, case reports, and observational studies with abstracts written in English were searched by using the keywords “Acupuncture and Endometriosis” in databases such as PubMed, Web of Science, and CINAHL. The reporting guidelines, Standards for Reporting Interventions in Clinical Trials of Acupuncture was used for the methodological report.
Results: Three studies were found including 99 women, 13–40 years old, with diagnosed endometriosis. The studies were different in research design, needle stimulation techniques, and evaluation instruments. Methodological similarities were seven to12 needle insertions per subject/session, and 15–25 minutes of needle retention time. The needles were placed in lower back/pelvic-abdominal area, in the shank, feet, and hands. Treatment numbers varied from nine to 16 and patients received one to two treatments per week. Similarity in reported treatment effects in the quoted studies, irrespective of research design or treatment technique, was reported decrease of rated pain intensity.
Discussion: Meta-analysis is the standard procedure for the evaluation of evidence of treatment effects, ie, on a group level, usually without analysis of the individual responses even with obvious spread in the results leading to lack of guidance for treatment of the individual patient. By conceptualizing pain as subjective, the individual aspect should serve as the basis for the analysis to allow clinical recommendations. From a physiological and a western medical perspective, acupuncture can be regarded as a type of sensory stimulation that induces changes in the function of the central nervous system that partly can explain the decrease of perceived pain in response to acupuncture treatment irrespective of the technique.
Conclusion: Endometriosis is often painful, although with various origin, where standard treatments may be insufficient or involve side effects. Based on the reported studies, acupuncture could be tried as a complement as it is an overall safe treatment. In the future, studies designed for evaluating effectiveness between treatment strategies rather than efficacy design would be preferred as the analyses of treatment effects in the individual patients.
Keywords: acupuncture, endometriosis, pelvic pain, pain treatment, STRICTA, individual responses
Endometriosis is described as a multifactorial, estrogen-dependent inflammatory gynecological condition that can result in long-lasting visceral pelvic pain and infertility.1,2 It can also be associated with irritable bowel syndrome and or interstitial cystitis/painful bladder syndrome.3 The condition is common worldwide, affecting approximately 5%–15% of women in reproductive age.4
One discussed possible mechanism for the onset of endometriosis is retrograded menstrual bleeding including endometrial tissue, often referred to as lesions, that is, manifested outside the uterus in diverse anatomical locations in the abdominal/pelvic cavity,5–7 and manifested as deep infiltrating endometriosis.8 An interactive and imbalanced function of sensory and autonomic nerve fibers innervating the extra-uterine lesions may maintain the endometriosis-related inflammatory process and one possible source of pain.8–11 Secondary ischemic reactions in local tissue and local nerve lesions (nerve distortion, compression, or damage) have also been discussed as the sources of the endometriosis-related pain.12,13 The pain, often long lasting, can be intermittent or continuous, appears as dysmenorrhea, dyspareunia, and/or dyschezia and, can be characterized as dull, throbbing, sharp, and burning, which sometimes is exacerbated by physical activity.3,14 Moreover, local muscular trigger points that are related to endometriosis can induce both local and referred pain which in turn results in lower pain thresholds in the painful area.15
The abnormal existence of the extra-uterine lesions is confirmed by diagnostic laparoscopy and frequently staged I–IV (ranging from I, indicating minimal disease, to IV, indicating severe disease) according to the American Society for Reproductive Medicine.16 The staging refers to the type, location, appearance, and depth of invasion of the lesions but is not always associated with the patients’ perceived pain intensity or severity, and vice versa.1,8,9
The endometriosis related changes may be due to plastic changes in the peripheral and central nervous system that possibly predispose for other long-lasting pain conditions,3 therefore identifying pain alleviation strategies is of great importance. The present clinically offered therapies aim to alleviate pain by different mechanisms that often consist of various types of pharmacological and surgical treatments. However, many of these interventions do not affect the perceived pain sufficiently or there can be a relapse of pain,17–19 and sometimes the therapies come with considerable side effects.20
Non-pharmacological treatment strategies based on sensory stimulation which includes different types of acupuncture, could serve as a complementary alternative. The pain-alleviating effects induced by acupuncture have been attributed to different physiological and psychological processes such as activation of endogenous descending pain inhibitory systems, deactivation of brain areas transmitting sensations of pain-related unpleasantness, interaction between nociceptive impulses and somato-visceral reflexes, and as a method that induces the expectation of symptom relief.21–23 Although acupuncture is widely used to manage long-term pain,24 it is still controversial. However, it has been described as a safe treatment method with very few reported serious side effects, provided that it is carried out by a skilled therapist,25,26 and a potent pain-alleviating treatment method for different long-term pain condition.27,28 Its pain-alleviating effects in comparison with various controlled conditions were reported by MacPherson et al,29 but they have been questioned by others.30 Earlier overviews, based on studies with a randomized clinical trial design, have discussed the reported clinical pain alleviating effects of acupuncture on endometriosis pain as limited31,32 and suggest that future studies preferably should be properly randomized and double-blinded.31 To get an overall picture of what is clinically known within the field, it would be beneficial to analyze studies with different design types, even though they are not double-blinded as double-blinding studies with acupuncture or having accurate placebo controls are a great challenge.33,34
Ideally, treatment should be individually tailor based,35–37 that is, based on the individual’s specific symptoms and needs as pain is perceived differently in different individuals, and the same type of symptom may have different implications for different women.2 Consequently, to increase the understanding of a patient’s level of pain and as a base for clinical decisions about treatment, it would be of interest to evaluate both the individual responses of those participating in a study, as well as the responses of the entire study group.
This work aims to summarize documented effects of acupuncture, applied with different techniques, on rated visceral pelvic endometriosis-related pain and associated variables among individuals as well as within and between studied groups. Also, methodological aspects of the treatment that may influence the results will be discussed.
This paper is a literature review of documented clinical studies evaluating acupuncture effects on endometriosis-related pelvic pain. The inclusion criteria were full text articles of clinical trials, case reports, and observational studies with abstracts written in English. The available literature was found using the keywords “Acupuncture AND Endometriosis” in the databases such as PubMed, Web of Science, and CINAHL.
The methodological aspects of the acupuncture treatment in the criteria met articles were in this review reported according to STandards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA).38 STRICTA is a reporting guideline that is primarily designed to improve the completeness and transparency of reporting in clinical trials of acupuncture. The guideline is conducted in agreement between the STRICTA group and the Consolidated Standards of Reporting Trials group in collaboration with the Chinese Cochrane Centre, and the Chinese Centre for Evidence-based Medicine.
The search resulted in a total of five articles published between 2006 and 2010.39–43 Two of the five articles were excluded since one of them42 reported developed methodological discussions applied to the same material as one of the other included articles, and the other article excluded40 was written as an explanatory protocol for Japanese acupuncture technique. Consequently, three articles were included in the present overview.39,41,43
Research design, outcome variables, and patients’ data
Two of the studies41,43 were performed using a prospective randomized, single-blind placebo/sham design, with one of them also having a crossover design.43 The third study39 was a retrospective observational case series study based on the history of two adolescent girls with endometriosis and severe pelvic pain treated with acupuncture.
In total 121 women, 13–40 years old, with diagnosed endometriosis stage I–IV according to the American Society for Reproductive Medicine, were included in the studies for acupuncture treatment of their endometriosis-related pain (Table 1).
In all three studies, the patient-rated pain intensity was the primary outcome variable, although evaluated with the use of different uni-dimensional rating scales (Visual Analog Scale, Numeric Rating Scale, and Verbal Rating Scale). In two of the studies, patients pain intensity was rated on the scale’s upper half39,43 before the start of the treatment, while the patients’ pain intensity ratings, in the study by Wayne et al,41 was spread from the lower part of the scale to its upper. The women also rated their health-related quality of life (HRQOL) in two of the studies41,43 with different multidimensional instruments (SF-36, Endometriosis Health Profile-30, and The Paediatric Quality of Life Inventory). Additional outcome variables in the study of Rubi-Klein et al43 were rated pain disability, patients’ treatment expectation, take home baby rate, number of absent days, and analgesic intakes. Wayne et al41 additionally asked their patients to rate their perceived symptom severity by their perceived stress. Also, the presence of serum inflammatory markers was measured in the same study. In the retrospective case series study by Highfield et al,39 the two adolescent girls also responded to questions on the symptom of the greatest concern, eg, fatigue, constipation, medication, and attendance at school. Description of assessment instruments and time-point for assessment are described in Table 1.
Methodological aspects on acupuncture according to STRICTA
Methodological aspects of the treatment procedures that are described by items in the checklist according to STRICTA are presented in Table 2. Two of the studies used acupuncture techniques based on traditional Chinese medicine and Japanese acupuncture technique, all individually tailor based on the patient’s symptoms.
The selection of acupuncture points varied between the studies, but they were in summary anatomically located in the lower back/pelvic region, in the lower abdominal area, and also in the hands and feet. The points were intra segmentally related to visceral organ innervation. One of the studies41 also described the additional use of auricular acupuncture points.
Stimulation depth in the three studies varied from being intracutaneous and subcutaneous to being intramuscular. The stimulation was mainly manual but with different intensity characterized by a needle sensation, deQi, in the studies of Highfield et al39 and Rubi-Klein et al,43 while a sensation described as weaker or more gentle than the deQi sensation and characterized as an “echo” in the therapist’s hand was sought for in the study by Wayne et al.41 Moxa applied on the needles were described in all three studies as a possibility when regarded as appropriate.
The needle insertions per subject and treatment session were 7–12, and the needle retention time described as 15–20 minutes. The number of treatments varied from 9 to 16 among the three studies and the treatment frequency was presented as twice a week in works by Wayne et al41 and Rubi-Klein et al,43 while Highfield et al39 described that as in average a little bit more than once a week. Continuation with the regular analgesic intervention was reported in two of the studies.39,43
Two of the three studies were aimed to evaluate the efficacy of acupuncture as compared to a control group. As a control method, Rubi-Klein et al43 used non-specific acupuncture points (ie, well-defined acupuncture points according to traditional Chinese medicine principles are unrelated to endometriosis) that in this case were located on the head, shoulder, chest, and thigh. The non-specific acupuncture points were stimulated less, described as a constant subcutaneous neutral needling technique, as compared to the “real” acupuncture technique where a needling sensation often in intramuscular tissue was sought for. This study also had a crossover design, meaning that the groups changed the type of treatment. Wayne et al41 used the non-penetrating Streitberger needles as a control treatment where these needles were attached to the skin over non-acupuncture points close to (1 cm away) defined acupuncture points in the forearm, shank, and foot. The treatments were performed at a hospital,39,43 in the acupuncturist’s office, or in the patient’s home.41
Reported treatment results
The first two studies41,43 reported a dropout among their patients, 18 and four patients respectively, resulting in a total of 99 women who were included in the analysis of treatment effects, as shown in Table 3.
Within group effects
In all three studies,39,41,43 the patients rated their pain intensity lower after acupuncture treatment, regardless of the acupuncture technique, as compared to before the start of the treatment period. Another aspect of pain evaluation, rated pain disability, used by Rubi-Klein et al43 was rated lower after treatment.
Also, the treated patient rated their HRQOL higher in two of studies. Decrease of analgesic intake and perceived stress within the acupuncture-treated groups were reported in the studies of Rubi-Klein et al43 and Wayne et al,41 respectively. In the observational study by Highfield et al,39 the social activity and attendance in school activity were reported as increased after the treatment period.
Between group effects
Systematic differences between the treatment group and the control group in the evaluation of rated pain intensity and the HRQOL subgroups “social efficiency” and “psychological well-being” were demonstrated in the Rubi-Klein et al study.43 A long-lasting effect of acupuncture on perceived pain in the same study made it difficult to interpret the effect of control treatment after being giving the “real” acupuncture.
In the study by Wayne et al,41 there were also some effects reported but there was not enough evidence to establish systematic differences between the groups in any of the used outcome variables.
This review is based on the results of evaluating three studies39,41,43 treatment effects of acupuncture, performed with different techniques, on rated endometriosis-related pelvic pain and associated variables. The studies also comprised of different study design and different number of patients included; two of the studies had a small number of patients, and a different number of evaluation instruments.
In all three studies,39,41,43 within-group effects of rated pain intensity was demonstrated to be at lower levels after treatment than before the start of treatment. In two of them, there were also reported effects on rated HRQOL at a higher level after treatment than before.
In the two studies41,43 that were aimed to test the treatment efficacy by comparing the results from a group treated with acupuncture with a group treated with what was labeled as placebo, one showed systematic effects between the groups with advantage for the use of acupuncture43 while there was not enough evidence in the other, with a smaller number of patients.41
From a physiological and a western medical perspective, acupuncture can be regarded as a type of sensory stimulation that induces changes in the function of the central nervous system, which can partly explain the decrease of perceived pain in response to acupuncture treatment. Except for the needle stimulation, acupuncture also includes an inevitable tactile stimulation of the patient during the treatment that is also present when inserting needles subcutaneously into sites not related to endometriosis pain and even when attaching the Streitberger needle. Therefore, it is still not possible to present a valid inert placebo control for adequate comparisons between groups since all types of hitherto present placebo models comprise some kind of afferent nerve activity.33 Consequently, perhaps the applied placebo controls used in the present studies could physiologically be regarded as types of acupuncture stimulation.
Despite differences between the studies, there were also similarities that the acupuncture points were located in the lower back/pelvic and abdominal area, in the shank, feet, and hands, and the points were stimulated for 15–25 minutes per treatment. The treatment sessions were repeated for 9–16 times with a frequency of 1–2 times/week. Another interesting and valuable aspect is that there were no reported side effects in any of the studies.
This could indicate that different acupuncture stimulation techniques, shallow or more intense, with needles inserted superficially or more deeply, may alleviate pain and increase in quality of life in women with endometriosis-related pelvic pain. Current literature however, gives no support to determine what type of acupuncture stimulation is the most effective. On the other hand, maybe all mentioned types could be available in clinical decisions as complementary pain-alleviating treatment depending on what is the best choice for the individual patient. According to the principles of evidence-based medicine, there is a need for practical aspects to be included to find a firm basis for clinical decisions aside from ‘hard evidence’ relating to what is found in groups of patients.44
Summarized data from many studies are often included in meta-analysis with the aim of describing the different study effect sizes and are standard procedure for the evaluation of evidence on a group level. However, one shortcoming is that the individual responses are usually not analyzed even with obvious spread in the results leading to a lack of guidance for the treatment of the individual. The conceptualizing of pain as a subjective experience leads to the need to find other methods of determining clinical effects than those relying on group-derived comparisons that apply uniform standards to all patients.36 Moreover, all results from therapies effect size obtained from meta-analysis is not interpretable when the studies’ evaluation instruments are based on the patients’ subjective experience of pain, for example Vickers et al27 presented a recalculated meta-analysis where the individual aspects were considered, and they concluded that acupuncture can be regarded as having potential effects in different long-term pain conditions. As severe endometriosis-related pain can be related to different possible causes, such as inflammatory or neuropathic, it also needs to be taken into consideration the evaluation of treatment effects.45
This review includes articles written in the English language, which was a base for evaluation of the articles, but can perhaps be seen as a limitation of the number of articles included. The commented studies in this report have a limited number of patients making patterns of changes even more variable than if they had included a larger number of patients. In order to strengthen decision making for clinical treatment, it would therefore be desirable that a larger number of patients were included in future studies. Also, in future studies it would be desirable to make comparisons between different treatment strategies that are probably more accurate, and to perform individual analyses.
Endometriosis is often presented with severe pain of various genesis, where the different usual/standard treatment forms may be inadequate or involve side effects. Based on the analysis in the presented review, there are grounds to believe that acupuncture can relieve pain in some patients. The effects of acupuncture as a pain-relieving treatment has in various studies been presented as an overall safe alternative treatment with very few and small (harmless) side effects, and furthermore with no effect on the environment. It could therefore also be regarded as a ‘sustainable’ treatment. In the future, studies designed for evaluating effectiveness between different types of treatment strategies, rather than efficacy design would be preferred to analyze treatment effects in individual patients.
The authors report no conflicts of interest in this work.
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