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Invasive pulmonary infection due to Thermoascus crustaceus in a kidney transplant recipient

Authors Mareș M, Moroti-Constantinescu VR, Voroneanu L, Doroftei F, Covic A, Mederle OA

Received 19 March 2019

Accepted for publication 17 June 2019

Published 3 July 2019 Volume 2019:12 Pages 1929—1934

DOI https://doi.org/10.2147/IDR.S209164

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 2

Editor who approved publication: Dr Joachim Wink


Mihai Mareș,1,* Valentina-Ruxandra Moroti-Constantinescu,2,3,* Luminița Voroneanu,4,5 Florica Doroftei,6 Adrian Covic,4,5 Ovidiu-Alexandru Mederle7

1Laboratory of Antimicrobial Chemotherapy, Ion Ionescu de la Brad University, Iași, Romania; 24th Department, “Matei Balș” National Institute of Infectious Diseases, Bucharest, Romania; 3Department of Infectious Diseases, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania; 4Department of Nephrology, “Gr. T. Popa” University of Medicine and Pharmacy, Iași, Romania; 5Renal Transplantation Center, “C. I. Parhon” Clinical Hospital, Iași, Romania; 6Intelcentru, “Petru Poni” Institute of Macromolecular Chemistry, Iași, Romania; 7Department of Microscopic Morphology/Histology, Angiogenesis Research Center, “Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania

*These authors contributed equally to this work

Abstract: The first case of invasive pulmonary infection due to the thermophilic fungus Thermoascus crustaceus in a kidney transplant recipient is described. For the identification of the fungal isolate, morphological aspects and molecular analysis have been used. The case report emphasizes this fungal species as an opportunistic human pathogen and underlines the importance of an accurate laboratory diagnosis for the correct management of the patient.

Keywords: Thermoascus crustaceus, thermophilic fungi, pulmonary infection, caspofungin, immunosuppression

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