Menu
Back to Journals » Infection and Drug Resistance » Volume 15
Intrinsic Resistance: A Significant Characteristic in Evaluating Antibiotic Sensitivity Pattern [Letter]
Received 4 March 2022
Accepted for publication 11 March 2022
Published 5 April 2022 Volume 2022:15 Pages 1515—1516
DOI https://doi.org/10.2147/IDR.S364959
Checked for plagiarism Yes
Editor who approved publication: Professor Suresh Antony
Nitin Kumar,1 Harit Kumar2
1Department of Microbiology, Symbiosis Medical College for Women, Symbiosis International (Deemed University), Lavale, Pune, Maharashtra, India; 2Department of Microbiology, Maharishi Markandeshwar Institute of Medical Science & Research, Maharishi Markandeshwar (Deemed to be) University, Mullana, Mullana, Haryana, India
Correspondence: Harit Kumar, Department of Microbiology, Maharishi Markandeshwar Institute of Medical Science & Research, Maharishi Markandeshwar (Deemed to be) University Mullana, Haryana, India, Email [email protected]
View the original paper by Mr Woreta and colleagues
A Response to Letter has been published for this article.
Dear editor
We have read study titled “Antibiotic Susceptibility Pattern and Bacterial Spectrum Among Patients with External Eye Infections at Menelik II Referral Hospital in Addis Ababa, Ethiopia”1 with keen interest for knowing antibiotic profile of organisms causing external eye infection at a referral hospital of Ethiopia as per Clinical and Laboratory standards Institute (CLSI) guidelines.
We would like to add some comments regarding antibiotic susceptibility pattern of isolates which need to be reviewed urgently in this study:
- This study reported Providencia stuartii as 100% sensitive (only one strain isolated and tested) to Ampicillin, Gentamicin and Tobramycin whereas P. stuartii is considered intrinsically resistant to several antibiotics including Ampicillin, Gentamicin and Tobramycin.2,3 The bacteria with intrinsic resistance to antibiotic should be reported “Resistant” only.2 Moreover, the intrinsic resistance is highly important as it along with other resistance mechanism may result in poor clinical outcome.4,5
- Further, this study reported 16.7% (1 out of 6 strains) resistance in Streptococcus pneumoniae to penicillin. However, CLSI guidelines have not recommended to report penicillin resistant S. pneumoniae strains on the basis of disk diffusion method(s).2
- The study was started from January, 2019 but the authors had used CLSI M100 guidelines of 2017. In the modern world of increasing anti-microbial resistance, CLSI updates M100 guidelines on yearly basis introducing variety of antimicrobial combinations against multi-drug and pan-drug resistant isolates. Since the author is dealing with antibiotic susceptibility pattern, so the latest CLSI guidelines must have been used. If still authors want to adhere to old CLSI guidelines then a short explanation in published paper might be of great importance.
However, we thank to the authors to do a highly efficient work on one of the most concerning areas in medical science and making it available to all.
Disclosure
Nitin Kumar is first author, second & corresponding author is Harit Kumar. The authors declare no conflicts of interest in this communication.
References
1. Woreta AN, Kebede HB, Tilahun Y, Teklegiorgis SGS, Abegaz WE. Antibiotic susceptibility pattern and bacterial spectrum among patients with external eye infections at Menelik II referral hospital in Addis Ababa, Ethiopia. Infect Drug Resist. 2022;15:765–779. doi:10.2147/IDR.S352098
2. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing.
3. Hayakawa K, Marchaim D, Divine GW, et al. Growing prevalence of Providencia stuartii associated with the increased usage of colistin at a tertiary health care center. Int J Infect Dis. 2012;16(9):e646–e648. doi:10.1016/j.ijid.2012.05.1029
4. Al Hamdan AS, Alghamdi AA, Alyousif GF, et al. Evaluating the prevalence and the risk factors of gram-negative multi-drug resistant bacteria in Eastern Saudi Arabia. Infect Drug Resist. 2022;15:475–490. doi:10.2147/IDR.S350048
5. Rus M, Licker M, Musuroi C, et al. Distribution of NDM1 carbapenemase-producing proteeae strains on high-risk hospital wards. Infect Drug Resist. 2020;13:4751–4761. doi:10.2147/IDR.S280977
© 2022 The Author(s). This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.
By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.