Back to Journals » Nutrition and Dietary Supplements » Volume 7

Intrinsic association between diet and the gut microbiome: current evidence

Authors Winglee K, Fodor A

Received 10 June 2015

Accepted for publication 5 September 2015

Published 7 October 2015 Volume 2015:7 Pages 69—76

DOI https://doi.org/10.2147/NDS.S62362

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Elizabeth Steels

Peer reviewer comments 2

Editor who approved publication: Dr Chandrika Piyathilake


Kathryn Winglee, Anthony A Fodor

Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA

Abstract: The gut microbiome performs many crucial functions for the human host, but the molecular mechanisms by which host, microbe, and diet interact to mediate health and disease are only starting to be revealed. Here, we review the literature on how changes in the diet affect the microbiome. A number of studies have shown that within a geographic region, different diets (such as vegan vs omnivore) are associated with differences in a modest number of taxa, but do not reliably produce radical differences within the gut microbial community. In contrast, studies that look across continents consistently find profoundly different microbial communities between Westernized and traditional populations, although it remains unclear to what extent diet or other differences in lifestyle drive these distinct microbial community structures. Furthermore, studies that place subjects on controlled short-term experimental diets have found the resulting alterations to the gut microbial community to generally be small in scope, with changes that do not overcome initial individual differences in microbial community structure. These results emphasize that the human gut microbial community is relatively stable over time. In contrast, short-term changes in diet can cause large changes in metabolite profiles, including metabolites processed by the gut microbial community. These results suggest that commensal gut microbes have a great deal of genetic plasticity and can activate different metabolic pathways independent of changes to microbial community composition. Thus, future studies of how the diet impacts host health via the microbiome may wish to focus on functional assays such as transcriptomics and metabolomics, in addition to 16S rRNA and whole-genome metagenome shotgun analyses of DNA. Taken together, the literature is most consistent with a model in which the composition of the adult gut microbial community undergoes modest compositional changes in response to altered diet but can nonetheless respond very rapidly to dietary changes via up- or downregulation of metabolic pathways that can have profound and immediate consequences for host health.

Keywords: microbiome, transcriptomics, metabolomics, 16S rRNA, diet

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]