Insulin autoimmune syndrome in a patient with ANCA-associated glomerulonephritis
Tsuneyoshi Ka1, Yuji Moriwaki1, Takeshi Nakanishi2, Tetsuya Yamamoto1
Divisions of 1Endocrinology and Metabolism, and 2Kidney and Dialysis, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
Abstract: The patient, a 66-year-old woman, who has been under hemodialysis due to antineutrophil cytoplasm autoantibody (ANCA)-associated glomerulonephritis since 2003, was hospitalized because of cold sweating, general fatigue, and somnolence. Hypoglycemia (43 mg/dL) with markedly elevated insulin level (1410 µU/mL) and insulin antibody was found in her serum. She was diagnosed as having insulin autoimmune syndrome. She has not taken any medication that might cause insulin autoimmune syndrome. The possible association of ANCA-associated glomerulonephritis with insulin autoimmune syndrome is discussed.
Keywords: hypoglycemia, insulin antibody, ANCA, insulin autoimmune syndrome
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