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Ingested capsaicinoids can prevent low-fat–high-carbohydrate diet and high-fat diet-induced obesity by regulating the NADPH oxidase and Nrf2 pathways

Authors Sahin K, Orhan C, Tuzcu M, Sahin N, Ozdemir O, Juturu V

Received 14 August 2017

Accepted for publication 30 September 2017

Published 13 November 2017 Volume 2017:10 Pages 161—168

DOI https://doi.org/10.2147/JIR.S149087

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Colin Mak

Peer reviewer comments 2

Editor who approved publication: Dr Ning Quan

Kazim Sahin,1 Cemal Orhan,1 Mehmet Tuzcu,2 Nurhan Sahin,1 Oguzhan Ozdemir,2 Vijaya Juturu3

1Department of Animal Nutrition, Veterinary Faculty, Firat University, Elazig, Turkey; 2Department of Biology, Faculty of Science, Firat University, Elazig, Turkey; 3Scientific and Clinical Affairs, Research and Development, OmniActive Health Technologies, Inc., Morristown, NJ, USA

Objective: Capsaicinoids (CAPs), most commonly found in chili peppers, have a multitude of pharmacological and physiological effects, such as anti-inflammation, antioxidant, and anticancer effects. In the present study, we set out to investigate the hypothesis that CAPs mitigate obesity in rats and the possible mechanisms thereof.
Materials and methods: Rats were divided into six groups, including control (±10 mg CAPs/kg body weight [BW]), low-fat–high-sucrose diet (±10 mg CAPs/kg BW), and high-fat diet (±10 mg CAPs/kg BW). Blood samples and liver and aortic tissues were taken at the end of the study.
Results: CAPs supplementation significantly reduced hyperglycemia and hyperlipidemia (P<0.001) and ameliorated oxidative damage by reducing malondialdehyde concentrations in serum and liver and by increasing total antioxidant capacity in serum induced by the low-fat–high-sucrose and high-fat diets (P<0.001 for all). CAPs also depressed levels of NFκB p65, gp91phox, and p22phox, essential components of NADPH oxidase, in the aorta of rats. However, levels of Nrf2, Sirt1, and endothelial nitric oxide synthase were significantly increased in the aorta.
Conclusion: CAPs may at least partially reduce adverse effects due to high-fat diet and sucrose consumption through regulation of energy metabolism, oxidative stress, and proteins involved in vasoprotection.

Keywords: capsaicinoids, metabolism, oxidative stress, lipid profile, antioxidant capacity

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