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Infliximab and biosimilar infliximab in psoriasis: efficacy, loss of efficacy, and adverse events

Authors Subedi S, Gong Y, Chen Y, Shi Y

Received 3 January 2019

Accepted for publication 28 May 2019

Published 23 July 2019 Volume 2019:13 Pages 2491—2502


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Georgios D. Panos

Smriti Subedi,1,2,* Yu Gong,1,2,* Youdong Chen,1,2, Yuling Shi1,2

1Department of Dermatology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China; 2Department of Dermatology, Institute of Psoriasis, Tongji University School of Medicine, Shanghai 200072, People’s Republic of China

*These authors contributed equally to this work

Abstract: Psoriasis is a chronic immune-mediated skin disease affecting multiple systems, and tumor necrosis factor-α (TNF-α) plays a significant role in the initiation and progression of the disease process. Psoriasis has a high prevalence rate in the Western world, especially in the USA and Australia; in China, although the prevalence rate is much lower, there is still a large number of patients suffering from psoriasis and its comorbidities. As TNF-α is thought to be crucial in the pathogenesis of psoriasis, specific therapy blocking TNF-α may be beneficial in the treatment of this disease. Infliximab, a murine–human monoclonal antibody, is highly efficacious in the treatment of moderate-to-severe psoriasis, with better skin clearance and faster onset of action than topical medications such as methotrexate, narrow-band ultraviolet B, and calcipotriol. Lack of adherence to infliximab therapy is mainly due to loss of response (LOR) over time and adverse events, particularly because infusion reactions are usually encountered. Anti-infliximab antibody is thought to be responsible for the LOR and infusion reactions. However, the mechanism underlying the formation of anti-infliximab antibody and its side effects remains unclear. Further studies identifying patients at risk for LOR will probably help clinicians to select the right patients for anti-TNF-α therapy and to increase the durability of the treatment. This review discusses the efficacy of infliximab as demonstrated by various clinical trials, LOR to infliximab, combatting LOR, as well as the adverse events usually faced during the use of infliximab therapy and the infliximab biosimilar Remsima®,. We hope that we can discover a better way to use infliximab in the therapy of psoriasis from the current research data.

Keywords: anti-infliximab antibody, infliximab, psoriasis, TNF-α, treatment

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