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Inflammation management in acute diverticulitis: current perspectives

Authors Ceresoli M, Lo Bianco G, Gianotti L, Nespoli L

Received 16 January 2018

Accepted for publication 28 March 2018

Published 30 May 2018 Volume 2018:11 Pages 239—246

DOI https://doi.org/10.2147/JIR.S142990

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Justinn Cochran

Peer reviewer comments 2

Editor who approved publication: Dr Ning Quan


Marco Ceresoli,1,2 Giulia Lo Bianco,1,2 Luca Gianotti,1,2 Luca Nespoli1,2

1Department of General Surgery, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy; 2School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy

Abstract: The pathogenesis of diverticular disease and acute diverticulitis is still unclear and many different hypotheses have been formulated. Seemingly, there are several related factors such as chronic inflammation, gut microbiome, obesity and the immunogenic properties of fat tissue and diet. Inflammation plays a pivotal role in diverticular disease and acute diverticulitis. The aim of the present review is to investigate the role of inflammation in diverticular disease as well as in mild and complicated acute diverticulitis with a focus on current research and treatment perspectives.

Keywords: acute diverticulitis, inflammation, diverticular disease.

A Letter to the Editor has been received and published for this article.


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