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Increased serum levels of apoptosis in deficit syndrome schizophrenia patients: a preliminary study

Authors Beyazyuz M, Kufeciler T, Bulut L, Unsal C, Albayrak Y, Soydas Akyol E, Baykal S, Kuloglu M, Hashimoto K

Received 23 February 2016

Accepted for publication 31 March 2016

Published 23 May 2016 Volume 2016:12 Pages 1261—1268

DOI https://doi.org/10.2147/NDT.S106993

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Papan Thaipisuttikul

Peer reviewer comments 2

Editor who approved publication: Dr Roger Pinder


Murat Beyazyüz,1 Tarkan Küfeciler,2 Leyla Bulut,3 Cüneyt Ünsal,1 Yakup Albayrak,1 Esra Soydaş Akyol,4 Saliha Baykal,1 Murat Kuloglu,5 Kenji Hashimoto6

1Department of Psychiatry, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey; 2Department of Emergency Medicine, Çekirge State Hospital, Bursa, Turkey; 3Department of Biochemistry, Okmeydani Education and Research Hospital, Istanbul, Turkey; 4Department of Psychiatry, Yenimahalle Education and Research Hospital, Ankara, Turkey; 5Department of Psychiatry, Faculty of Medicine, Akdeniz University, Antalya, Turkey; 6Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan

Background: Schizophrenia is a chronic and debilitating disorder, the etiology of which remains unclear. Apoptosis is a programmed cell death mechanism that might be implicated in neuropsychiatric disorders, including schizophrenia. In this study, we aimed to compare the serum levels of apoptosis among deficit schizophrenia (DS) syndrome patients, nondeficit schizophrenia (NDS) patients, and healthy controls (HCs).
Patients and methods: After the inclusion and exclusion criteria were applied, 23 DS patients, 46 NDS patients, and 33 HCs were included in the study. The serum apoptosis levels were measured using a quantitative sandwich enzyme immunoassay with human monoclonal antibodies directed against DNA and histones.
Results: There was a significant difference among the three groups in terms of the levels of apoptosis (F2,96=16.58; P<0.001). The serum apoptosis levels in the DS and NDS groups were significantly higher than those in the HC group. Furthermore, the serum apoptosis levels in the DS group were significantly higher than the levels in the NDS group.
Conclusion: This study suggests that increased levels of apoptosis may be implicated in the pathophysiology of DS syndrome. However, further studies are needed to support the role of apoptosis in DS.

Keywords: apoptosis, etiology, deficit, psychosis

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