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In vitro inhibitory activities of magnolol against Candida spp.

Authors Zhou PR, Fu JY, Hua H, Liu XS

Received 15 July 2017

Accepted for publication 17 August 2017

Published 6 September 2017 Volume 2017:11 Pages 2653—2661

DOI https://doi.org/10.2147/DDDT.S146529

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Akshita Wason

Peer reviewer comments 2

Editor who approved publication: Dr Anastasios Lymperopoulos

Peiru Zhou,1 Jingya Fu,2 Hong Hua,1 Xiaosong Liu1

1Department of Oral Medicine, Peking University School and Hospital of Stomatology, 2Department of Stomatology, Peking University International Hospital, Beijing, People’s Republic of China

Abstract: Candida spp. cause various infections involving the skin, mucosa, deep tissues, and even life-threatening candidemia. They are regarded as an important pathogen of nosocomial bloodstream infection, with a high mortality rate. As a result of prolonged exposure to azoles, the therapeutic failure associated with azoles resistance has become a serious challenge in clinical situations. Therefore, novel, alternative antifungals are required urgently. In the present study, the CLSI M-27A broth microdilution method and the 2,3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction assay were used to evaluate the antifungal effects of magnolol against various standard Candida strains in planktonic mode and biofilm formation, respectively. The antifungal activity of magnolol was demonstrated in planktonic C. albicans and non-albicans Candida species, especially fluconazole-resistant Candida krusei, with the minimum inhibitory concentrations ranging from 10 to 40 µg/mL. The BMIC90 (minimum concentration with 90% Candida biofilm inhibited) values of magnolol ranged from 20 to 160 µg/mL, whereas the BMIC90 values of fluconazole were more than 128 µg/mL. As an alternative and broad-spectrum antifungal agent, magnolol might be of benefit to the treatment of refractory Candida infection.

Keywords: magnolol, inhibition, Candida spp., biofilm
 

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