Back to Journals » Breast Cancer: Targets and Therapy » Volume 4

Implications for breast cancer dormancy in other areas of medicine

Authors Rameshwar P

Received 6 August 2012

Accepted for publication 6 August 2012

Published 5 December 2012 Volume 2012:4 Pages 193—195


Checked for plagiarism Yes

Pranela Rameshwar

New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA

Banys et al1 discussed the different viewpoints of breast cancer dormancy; albeit those that are supported by science. This editorial comments on the clinical implications of existing dormant cancer cells, including future decisions to treat with stem cells.
Braun et al2 reported that in cases where metastasis of breast cancer occurred in the bone marrow, this resulted in poor prognosis. As discussed by the authors, it is unclear whether breast cancer cells show tropism for an organ, or whether the cells are able to survive in a particular organ because of support from the microenvironment. Perhaps answers to this question might be clearer if a hierarchy of breast cancer cells is developed, beginning with the cancer stem cell. Depending on the cell subset, there might be a different mechanism for dormancy in an organ.

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]