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Impact of vitamin D on spirometry findings and quality of life in patients with chronic obstructive pulmonary disease: a randomized, double-blinded, placebo-controlled clinical trial

Authors Alavi Foumani A, Mehrdad M, Jafarinezhad A, Nokani K, Jafari A

Received 2 March 2019

Accepted for publication 17 May 2019

Published 8 July 2019 Volume 2019:14 Pages 1495—1501

DOI https://doi.org/10.2147/COPD.S207400

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Melinda Thomas

Peer reviewer comments 2

Editor who approved publication: Dr Richard Russell


Ali Alavi Foumani,1 Mojtaba Mehrdad,1,2 Alireza Jafarinezhad,1 Khadijeh Nokani,3 Alireza Jafari1

1Inflammatory Lung Diseases Research Center, Department of Internal Medicine, Razi Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran; 2Razi Clinical Research Development Center, Guilan University of Medical Sciences, Rasht, Iran; 3Student Research Committee, Department of Internal Medicine, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran

Abstract: COPD is an irreversible chronic illness with airflow limitation. The aim of the current study was to assess the role of vitamin D3 on quality of life and pulmonary function in patients with COPD. A randomized, double-blinded clinical trial was conducted in 63 patients with COPD. Patients were placed into intervention and placebo groups. Each individual in the intervention group took 50,000 IU vitamin D3once a week for 8 weeks and then once a month for 4 months. There was no significant difference among FEV1, FEV1/FVC, and number of exacerbations in patients with COPD (P>0.05). In the intervention group, a significant difference was observed in quality of life at 2 months (P<0.001) and 6 months (P<0.001). In addition, qualitative analysis showed that the status of exacerbation had not got worse six months after initiation in the intervention group. The current study shows that consumption of 50,000 IU vitamin D3, as a convenient supplementation in a daily diet, is able to increase quality of life in patients with COPD.

Keywords: airflow obstruction, chronic, 25-hydroxyvitamin D3, life quality

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