Impact of exacerbations on respiratory system impedance measured by a forced oscillation technique in COPD: a prospective observational study
Authors Kamada T, Kaneko M, Tomioka H
Received 16 October 2016
Accepted for publication 10 December 2016
Published 3 February 2017 Volume 2017:12 Pages 509—516
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Amy Norman
Peer reviewer comments 2
Editor who approved publication: Dr Richard Russell
Takahiro Kamada, Masahiro Kaneko, Hiromi Tomioka
Department of Respiratory Medicine, Kobe City Medical Center West Hospital, Kobe, Japan
Background: Forced oscillation technique (FOT) has been reported to be useful in the evaluation and management of obstructive lung disease, including COPD. To date, no data are available concerning long-term changes in respiratory system impedance measured by FOT. Additionally, although exacerbations have been reported to be associated with excessive lung function decline in COPD, the impact of exacerbations on the results of FOT has not been demonstrated. The aim of this study was to investigate the longitudinal changes in respiratory system impedance and the influence of exacerbations thereon.
Methods: Between March 2011 and March 2012, outpatients who attended Kobe City Medical Center West Hospital with a diagnosis of COPD were assessed for eligibility. Baseline patient characteristics (age, sex, body mass index, smoking history, current smoking status, COPD stage), lung function (post-bronchodilator forced expiratory volume in 1 second [FEV1]), blood tests (neutrophils and eosinophils), FOT, and COPD assessment test results were collected at enrollment. Lung function and FOT were examined every 6 months until March 2016. Annual changes in FEV1 and FOT parameters were obtained from the slope of the linear regression curve. The patients were divided into 2 groups based on exacerbation history.
Results: Fifty-one of 58 patients with COPD were enrolled in this study. The median follow-up period was 57 (52–59) months. Twenty-five (49%) patients experienced exacerbations. A significant annual decline in FEV1 and respiratory system impedance were shown. Additionally, annual changes in FEV1, respiratory system resistance at 5 Hz, respiratory system reactance at 5 Hz, and resonant frequency were greater in patients with exacerbations than in those without exacerbations.
Conclusion: Exacerbations of COPD lead not only to a decline in lung function but also to an increase in respiratory system impedance.
Keywords: chronic obstructive pulmonary disease, forced oscillation technique, lung function tests, respiratory system, impedance, resistance
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