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Ibuprofen Arginate for Rapid-Onset Pain Relief in Daily Practice: A Review of Its Use in Different Pain Conditions

Authors Cajaraville JP

Received 11 September 2020

Accepted for publication 11 November 2020

Published 25 January 2021 Volume 2021:14 Pages 117—126


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 5

Editor who approved publication: Dr Robert B. Raffa

Juan Pérez Cajaraville

Pain Unit, Grupo Hospitalario Universitario HM (Hospitales de Madrid), Madrid, Spain

Correspondence: Juan Pérez Cajaraville
Pain Unit, Grupo Hospitalario Universitario HM (Hospitales de Madrid), Pl. del Conde del Valle Súchil 16, Madrid E-28015, Spain
Tel +34 629200991

Abstract: Ibuprofen is one of the most frequently used analgesics. One of the concerns related with the oral administration of conventional ibuprofen is the relatively slow absorption, which is clinically a relative inconvenience when rapid-onset analgesic effect is required in patients suffering from acute moderate/severe pain. A new oral dosage formulation of ibuprofen containing the L-arginine salt of ibuprofen (ibuprofen arginate) has been commercialized for more than two decades, but data reported in the literature are relatively scarce. This article presents salient findings on pharmacokinetics, pharmacological activity, clinical efficacy and tolerability of ibuprofen arginate, with the purpose to provide clinicians with a summary overview of some frequent acute pain conditions, such as dental pain, dysmenorrhea, headache or postoperative pain in which ibuprofen arginate may be considered the drug of choice in individual patients.

Keywords: ibuprofen arginate, arginine, analgesic efficacy, pharmacokinetics

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