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Hypoxia and hyperbaric oxygen therapy: a review

Authors Choudhury R

Received 14 May 2018

Accepted for publication 10 August 2018

Published 20 November 2018 Volume 2018:11 Pages 431—442

DOI https://doi.org/10.2147/IJGM.S172460

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Ms Justinn Cochran

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser


Ryan Choudhury

Department of Internal Medicine, Graduate Medical Education, St Vincent Charity Medical Center, Cleveland, OH, USA

Abstract: Hypoxia causes a cascade of activity from the level of the individual down to the regulation and function of the cell nucleus. Prolonged periods of low oxygen tension are a core feature of several disease states. Advances in the study of molecular biology have begun to bridge the gap between the cellular response to hypoxia and physiology. Hyperbaric oxygen therapy is a treatment for hypoxic- and inflammatory-driven conditions, in which patients are treated with 100% oxygen at pressures greater than atmospheric pressure. This review discusses hypoxia, the physiologic changes associated with hypoxia, the responses that occur in the cells during hypoxic conditions, and the role that hyperbaric oxygen therapy can play as part of the treatment for many patients suffering from diseases with underlying hypoxia.

Keywords: hypoxia, physiology, oxygen signaling, cellular metabolism, hyperbaric oxygen therapy

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