Back to Journals » Clinical Optometry » Volume 10

Hypochlorous acid solution (Avenova®) is not demodicidal

Authors Kabat AG

Received 3 August 2018

Accepted for publication 9 August 2018

Published 2 October 2018 Volume 2018:10 Pages 115—117


Checked for plagiarism Yes

Editor who approved publication: Mr Simon Berry

Alan G Kabat

Pennsylvania College of Optometry, The Eye Institute, Salus University, Philadelphia, PA, USA

I read with great interest the recent manuscript entitled “Demodex blepharitis: clinical perspectives” by Fromstein et al in Clinical Optometry.1 I wish to commend the authors on a thorough and well-written review of the subject. However, I feel compelled to point out one very controversial point that I believe is erroneous and unfounded. 

Authors’ reply

Stephanie R Fromstein, Jennifer S Harthan, Jaymeni Patel, Dominick L Opitz

Department of Clinical Education, Illinois College of Optometry, Chicago, IL, USA

The work by Dr Kabat is of particular interest to us as this is the first study comparing the kill time of commercially available Cliradex® (Bio-Tissue, Inc, Miami, FL, USA) containing 4% terpinen-4-ol to commercially available Avenova® (NovaBay Pharmaceuticals, Inc, Emeryville, CA, USA) containing 0.01% hypochlorous acid, and 100% mineral oil. His work demonstrated statistically significant kill time with Cliradex® compared to Avenova®, but we found it particularly interesting that 21% of Demodex mites treated with Avenova® were killed within 90 minutes of exposure to Avenova® and that none of the mites exposed to mineral oil were killed.

View the original paper by Fromstein and colleagues.

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]