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Hyperuricemia is a biomarker of early mortality in patients with chronic obstructive pulmonary disease

Authors Zhang X, Liu LJ, Liang R, Jin SD

Received 23 April 2015

Accepted for publication 16 June 2015

Published 26 November 2015 Volume 2015:10(1) Pages 2519—2523

DOI https://doi.org/10.2147/COPD.S87202

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Editor who approved publication: Dr Richard Russell

Xin Zhang, Lijie Liu, Rui Liang, Shoude Jin

Department of Respiratory Medicine, Fourth Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China


Abstract: Patients with chronic obstructive pulmonary disease (COPD) are often at high risk of early death. Identification of prognostic biomarkers for COPD may aid in improving their survival by providing early strengthened therapy for high-risk patients. In the present study, we investigated the prognostic role of hyperuricemia at baseline on the prognosis of patients with COPD. Thirty-four patients with COPD with hyperuricemia were matched (1:2) to 68 patients with COPD without hyperuricemia and of similar age and sex. Data from those patients with COPD were evaluated retrospectively. The role of hyperuricemia on mortality was first analyzed using the Kaplan–Meier method, and multivariate Cox regression model was then used to evaluate the prognostic significance of hyperuricemia in patients with COPD. Hyperuricemia was not associated with other baseline characteristics in patients with COPD. Kaplan–Meier survival curve showed that patients with COPD with hyperuricemia had higher risk of mortality compared with patients with normouricemia, and the P-value for log-rank test was 0.005. In univariate analysis, hyperuricemia was associated with higher risk of mortality in patients with COPD (hazard ratio =2.29, 95% CI =1.07–4.88, P=0.032). In the multivariate analysis, hyperuricemia was independently associated with higher risk of mortality in patients with COPD (hazard ratio =2.68, 95% CI =1.18–6.09, P=0.019). In conclusion, hyperuricemia is a promising biomarker of early mortality in patients with COPD.

Keywords: hyperuricemia, chronic obstructive pulmonary disease, mortality, uric acid

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