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HOXB7 as a promising molecular marker for metastasis in cancers: a meta-analysis

Authors Liu F, Ou Y, Zhang G, Qiu C, Luo H, Zhu P

Received 11 January 2016

Accepted for publication 25 February 2016

Published 6 May 2016 Volume 2016:9 Pages 2693—2699

DOI https://doi.org/10.2147/OTT.S104000

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Chang Liu

Peer reviewer comments 2

Editor who approved publication: Dr William Cho


Fang-teng Liu, Yang-xi Ou, Guan-ping Zhang, Cheng Qiu, Hong-liang Luo, Pei-qian Zhu

Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China

Abstract: Numerous studies on carcinoma have revealed that the expression level of HOXB7 in cancerous tissues was significantly higher than that in noncancerous tissues. Elevated expression of HOXB7 is associated with the susceptibility to lymph node metastasis and distant metastasis in various tumors. In this study, a meta-analysis was performed to involve majority of relevant articles and explore the association of HOXB7 expression level with metastasis in cancer patients. Literature retrieval was conducted by searching in a number of electronic databases (up to December 1, 2015). The meta-analysis was conducted with RevMan 5.3 software and Stata SE12.0. A total of 1,532 patients with carcinoma from 14 studies were included in analysis. The results of meta-analysis demonstrated that lymph node metastasis was observed more frequently in the patients group with high expression level of HOXB7 than in the patients group with low expression level of HOXB7 (odds ratio =2.17, 95% CI: 1.74–2.71, P<0.00001, fixed-effects model). In addition, a similar result was observed in the association between HOXB7 expression and distant metastasis; the odds ratio was 1.77 (95% CI: 1.09–2.88, P=0.02, fixed-effects model). This meta-analysis demonstrated that the overexpression of HOXB7 was significantly associated with metastasis in cancer patients, which may be served as a common molecular marker for indicating cancer metastasis.

Keywords: homeobox gene, HOXB7, carcinoma, metastasis, meta-analysis

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