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Hirschsprung disease: current perspectives

Authors Moore SW

Received 20 November 2015

Accepted for publication 11 February 2016

Published 27 May 2016 Volume 2016:9 Pages 39—50


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Professor Cataldo Doria

SW Moore

Division of Paediatric Surgery, Faculty of Medicine, University of Stellenbosch, Cape Town, South Africa

Abstract: Hirschsprung disease is a complex congenital condition of the intestine, which is recognized as being of genetic origin and results from a disturbance of the normal development of the enteric nervous system. As a result, aganglionosis of the distal bowel occurs. It is the most common cause of a low intestinal obstruction in the neonate as well as older children. Occurring as an isolated condition in 70% of cases, it may be associated with other associated congenital abnormalities as well as a number of syndromic phenotypes. A number of distinct genetic sites have been identified in these syndromic phenotypes, which identify potential underlying genetic associations of the disease and indicate the probable gene–gene interaction in its pathogenesis. This review looks at the prevalence, congenital associations, and possible genetic factors influencing the development of Hirschsprung disease. Diagnostic dilemmas, surgical management, potential postsurgical complications, and outcomes are also explored.

Keywords: Hirschsprung disease, children, diagnosis, management, complications and outcome

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