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High preoperative serum prealbumin predicts long-term survival in resected esophageal squamous cell cancer

Authors Wei J, Jin M, Shao Y, Ning Z, Huang J

Received 30 April 2019

Accepted for publication 12 August 2019

Published 26 August 2019 Volume 2019:11 Pages 7997—8003


Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Dr Chien-Feng Li

Jun Wei,1 Ming Jin,2 Yingjie Shao,1 Zhonghua Ning,1 Jin Huang1

1Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People’s Republic of China; 2Department of Clinical Laboratory, The Third Affiliated Hospital of Soochow University, Changzhou 213003, People’s Republic of China

Correspondence: Zhonghua Ning; Jin Huang
Department of Radiation Oncology, The Third Affiliated Hospital of Soochow University, 185 Juqian Road, Changzhou 213003, People’s Republic of China
Tel +86 5 196 887 1132

Purpose: The current study aimed to explore the prognostic role of preoperative prealbumin in resectedesophageal squamous cell carcinoma (ESCC).
Methods: A total of 1374 resected ESCC patients were retrospectively reviewed. Serum for prealbumin analyses was taken within 1–3 days before the operation. Overall survival (OS) was determined using the Kaplan-Meier method; the univariate log-rank test and the multivariate Cox proportional hazard model were used to evaluate the prognostic role of prealbumin. A receiver operating characteristic (ROC) curve was plotted, and the area under the curve (AUC) was calculated to compare the prediction accuracy of prealbumin and albumin for OS.
Results: Finally, 532 patients were included in this study. The 5-year OS rate was favourable for the high prealbumin group versus the median and low prealbumin groups (58.1% vs 44.6% and 31.1%, respectively; P<0.001). Univariate and multivariate analyses identified serum prealbumin, T stage, N stage, differentiation and albumin as independent prognostic factors for OS. ROC curves indicated that prealbumin may be superior to albumin as a prognostic predictor in ESCC patients, but the difference between the two AUCs was not statistically significant (P=0.068).
Conclusion: Prealbumin is an independent prognostic factor and a prognostic indicator of postoperative outcomes in ESCC patients. Future prospective studies are warranted to confirm our results.

Keywords: oesophageal squamous cell carcinoma, prealbumin, albumin, prognosis, serum marker

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