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Hepatocellular cancer pain: impact and management challenges

Authors Christian-Miller N, Frenette C

Received 6 February 2018

Accepted for publication 16 May 2018

Published 19 July 2018 Volume 2018:5 Pages 75—80

DOI https://doi.org/10.2147/JHC.S145450

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Amy Norman

Peer reviewer comments 3

Editor who approved publication: Dr Ahmed O. Kaseb


Nathaniel Christian-Miller,1 Catherine Frenette2

1Scripps Clinical Research, Scripps, San Diego, CA, USA; 2Scripps Center for Organ and Cell Transplantation, Scripps Green Hospital, La Jolla, CA, USA

Abstract: Hepatocellular carcinoma (HCC) remains the most common primary liver malignancy. Pain comprises one of the most pervasive and troubling symptoms of HCC and may have severely negative effects on patient’s quality of life. Furthermore, because HCC frequently arises in the setting of cirrhosis, treating pain related to this malignancy poses a clinical challenge. This article summarizes manifestations of hepatocellular cancer pain, common obstacles to treatment, and practical HCC pain management.

Keywords: hepatocellular carcinoma, health-related QOL, analgesic, opioid, loco-regional therapy, cirrhosis

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