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Hemodynamic and Morphological Analysis of Mirror Aneurysms Prior to Rupture

Authors Yuan J, Huang C, Lai N, Li Z, Jiang X, Wang X, Zhao X, Wu D, Liu J, Xia D, Fang X

Received 16 March 2020

Accepted for publication 6 May 2020

Published 27 May 2020 Volume 2020:16 Pages 1339—1347


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Yuping Ning

Jinlong Yuan,1,* Chenlei Huang,2,* Niansheng Lai,1 Zhenbao Li,1 Xiaochun Jiang,1 Xuanzhi Wang,1 Xintong Zhao,1 Degang Wu,1 Jiaqiang Liu,1 Dayong Xia,1 Xinggen Fang1

1Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital), Wuhu, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Xinggen Fang Email [email protected]; [email protected]

Objective: Hemodynamic factors are thought to play important roles in the pathogenesis, progression, and rupture of cerebral aneurysms. Previous hemodynamic studies have been based on comparisons between post-ruptured and unruptured aneurysms. Nevertheless, changes of aneurysm morphology after rupture render these results unreliable. Moreover, pressure, age, gender, and the morphology of the parent artery also influence these results. Therefore, in the present study, we identified hemodynamic and morphological characteristics of aneurysms prior to rupture using twelve mirror aneurysms.
Materials and Methods: From our database, we retrospectively analyzed twelve mirror aneurysms (MANs) prior to rupture. Each mirror aneurysm was divided into the prior to rupture or the unruptured group. Patient-specific models were reconstructed from three-dimensional (3D) images of all patients. Hemodynamic and morphological factors were analyzed and compared.
Results: Compared with the unruptured side of MANs, aneurysms prior to rupture were significantly larger and significantly more irregular in shape; they also had significantly higher aspect ratio (AR), size ratio (SR), undulation index (UI), ellipticity index (EI), percentage of low wall shear stress area (LSA) and significantly lower normal wall shear stress (NWSS). The oscillatory shear index (OSI) and nonsphericity index (NSI) in the aneurysms prior to rupture were non-significantly higher than those of the unruptured group.
Conclusion: MANs prior to rupture may be extremely useful models to assess the risk of aneurysm rupture. Larger size, irregular shape, higher AR, SR, UI, NI, and lower WSS may be associated with aneurysms at risk for rupture.

Keywords: mirror aneurysms, computational fluid dynamics, hemodynamics, morphological, rupture

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