Back to Journals » Biologics: Targets and Therapy » Volume 15

Glomerulonephritis in Two Patients with SpA Treated with TNF-α Blockers and a Review of the Literature

Authors Bounia CA, Theodoropoulou EN, Liossis SNC

Received 22 December 2020

Accepted for publication 16 February 2021

Published 17 March 2021 Volume 2021:15 Pages 61—66

DOI https://doi.org/10.2147/BTT.S297712

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Doris Benbrook


Constantina A Bounia,1 Eftichia N Theodoropoulou,1 Stamatic-Nick C Liossis1,2

1Division of Rheumatology, Patras University Hospital, Patras, Greece; 2Department of Internal Medicine, University of Patras Medical School, Patras, Greece

Correspondence: Stamatic-Nick C Liossis
Div. of Rheumatology, Patras University Hospital, GR 26500, Rion, Patras, Greece
Tel +30 2613 603 693
Fax +30 2610 993 982
Email [email protected]

Abstract: Renal failure or acute/chronic kidney damage may present as a clinical manifestation of rheumatic diseases. In addition treatment with DMARDs or biologic drugs may induce nephrotoxicity. In this case-based review, we present two patients with SpA under anti-TNF-α treatment admitted to our hospital because of renal failure and proteinuria. We review previously published yet isolated cases of TNF-α blocker-induced glomerular disease in patients with SpA. Renal manifestations are occasionally seen in patients with ankylosing spondylitis and psoriatic arthritis with IgA nephropathy being the most common of them. Anti-TNF-α agents although reportedly used for the treatment of glomerular nephropathy as a disease manifestation, they have been considered responsible for provoking renal damage in some cases. A diagnostic approach for patients with SpA treated with anti-TNF-α agents presenting with renal manifestations is proposed herein.

Keywords: spondylarthritides, glomerular disease, proteinuria, kidney biopsy, anti-TNF-alpha agents

Creative Commons License This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

Download Article [PDF]  View Full Text [HTML][Machine readable]