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Glecaprevir/pibrentasvir for the treatment of chronic hepatitis C: design, development, and place in therapy

Authors Cotter TG, Jensen DM

Received 26 November 2018

Accepted for publication 27 June 2019

Published 29 July 2019 Volume 2019:13 Pages 2565—2577

DOI https://doi.org/10.2147/DDDT.S172512

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Frank M. Boeckler


Thomas G Cotter,1 Donald M Jensen2

1Center for Liver Diseases, The University of Chicago Medicine, Chicago, IL, USA; 2Section of Hepatology, RUSH University Medical Center, Chicago, IL, USA

Abstract: Direct-acting antiviral (DAA) therapy has changed the landscape of hepatitis C virus (HCV) management and has changed the focus to the possibility of HCV elimination in the near future. Glecaprevir, an NS3/4A protease inhibitor, and pibrentasvir, an HCV NS5A inhibitor, have addressed many of the existing shortcomings in the DAA therapy spectrum. This combination has proven to be a highly efficacious pan-genotypic DAA with a high barrier to resistance as a once-daily, all-oral medication. This review explores the design and development of glecaprevir and pibrentasvir, its place in current HCV management in the midst of a myriad of DAA therapy options, and also remaining challenges.

Keywords: glecaprevir, pibrentasvir, direct-acting antiviral therapy, hepatitis C virus


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