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Giant Intracranial Xanthoma with Cloudy Vision as the First Symptom: A Case Report and Literature Review

Authors Wang X, Li X, Liu X, Yin Y, Dang Y, Lei F

Received 20 November 2020

Accepted for publication 11 March 2021

Published 25 March 2021 Volume 2021:14 Pages 1101—1105


Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 3

Editor who approved publication: Dr Scott Fraser

Xueting Wang,1,2 Xuejiao Li,2 XuHui Liu,3 Yizhe Yin,1 Yalong Dang,2 Fang Lei1

1Department of Ophthalmology, Henan University of Science and Technology School of Medicine, Luoyang, Henan, 471000, People’s Republic of China; 2Sanmenxia Central Hospital, Henan University of Science and Technology, Sanmenxia, Henan, 472000, People’s Republic of China; 3Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450001, People’s Republic of China

Correspondence: Yalong Dang; Fang Lei Tel +86-398-3118149
; +86-379-64231886
Email [email protected]; [email protected]

Abstract: A 31-year-old male with mild dizziness complained of cloudy vision in his right eye for 5 days. The visual acuity of both eyes was normal, while the visual contrast sensitivity of both eyes slightly reduced. Fundus examination showed the swollen and radial superficial hemorrhage of his both optic nerves. Brain MRI scan indicated a huge tumor in the right temporal lobe with clear boundary, close to the skull. The midline structure shifted to the left. Blood tests indicated no hyperlipidemia or lipid disorders. The patient then received tumor resection. The size of the tumor was 5.6 cm × 7.5 cm × 10.1 cm. Histology suggested many foam cell accumulations and the tumor was positive for CD34, CD99, Vimentin, β-Catenin and CD68, but negative for EMA, GFAP, IDH-1, Oliga-2, PR, S-100, and CD1a. Three months after surgery, MRI showed the midline structure was back to normal. The swollen and radial superficial hemorrhage of optic nerves had disappeared. The visual acuity and visual field remained normal.

Keywords: intracranial xanthoma, optic nerve, visual function, neurological disorder, optic disc edema

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