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Genetic association between the dopamine D1-receptor gene and paranoid schizophrenia in a northern Han Chinese population

Authors Yao J, Ding M, Xing JX, Xuan JF, Pang H, Pan YQ, Wang BJ

Received 23 January 2014

Accepted for publication 20 February 2014

Published 17 April 2014 Volume 2014:10 Pages 645—652

DOI https://doi.org/10.2147/NDT.S61227

Checked for plagiarism Yes

Review by Single-blind

Peer reviewer comments 3

Jun Yao, Mei Ding, Jiaxin Xing, Jinfeng Xuan, Hao Pang, Yuqing Pan, Baojie Wang

Institute of Forensic Medicine, China Medical University, Shenyang, People's Republic of China

Objective: Dysregulation of dopaminergic neurotransmission at the D1 receptor in the prefrontal cortex has been implicated in the pathogenesis of schizophrenia. Genetic polymorphisms of the dopamine D1-receptor gene have a plausible role in modulating the risk of schizophrenia. To determine the role of DRD1 genetic polymorphisms as a risk factor for schizophrenia, we undertook a case-control study to look for an association between the DRD1 gene and schizophrenia.
Materials and methods: We genotyped eleven single-nucleotide polymorphisms within the DRD1 gene by deoxyribonucleic acid sequencing involving 173 paranoid schizophrenia patients and 213 unrelated healthy individuals. Statistical analysis was performed to identify the difference of genotype, allele, or haplotype distribution between cases and controls.
Results: A significantly lower risk of paranoid schizophrenia was associated with the AG + GG genotype of rs5326 and the AG + GG genotype of rs4532 compared to the AA genotype and the AA genotype, respectively. Distribution of haplotypes was no different between controls and paranoid schizophrenia patients. In the males, the genotype distribution of rs5326 was statistically different between cases and controls. In the females, the genotype distribution of rs4532 was statistically different between cases and controls. However, the aforementioned statistical significances were lost after Bonferroni correction.
Conclusion: It is unlikely that DRD1 accounts for a substantial proportion of the genetic risk for schizophrenia. As an important dopaminergic gene, DRD1 may contribute to schizophrenia by interacting with other genes, and further relevant studies are warranted.

Keywords: dopamine D1 receptor, paranoid schizophrenic, single-nucleotide study, association, genetic polymorphism

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Other article by this author:

Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis

Pan YQ, Yao J, Wang BJ

Neuropsychiatric Disease and Treatment 2014, 10:1133-1139

Published Date: 20 June 2014

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