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Gender, genetics, and analgesia: understanding the differences in response to pain relief

Authors Packiasabapathy S, Sadhasivam S

Received 13 April 2018

Accepted for publication 2 October 2018

Published 8 November 2018 Volume 2018:11 Pages 2729—2739

DOI https://doi.org/10.2147/JPR.S94650

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Katherine Hanlon


Senthil Packiasabapathy, Senthilkumar Sadhasivam

Department of Anesthesia, Riley Hospital for Children at Indiana University Health, Indianapolis, IN, USA

Abstract: Genetic variations and gender contribute significantly to the large interpatient variations in opioid-related serious adverse effects and differences in pain relief with other analgesics. Opioids are the most commonly used analgesics to relieve moderate-to-severe postoperative pain. Narrow therapeutic index and unexplained large interpatient variations in opioid-related serious adverse effects and analgesia negatively affect optimal perioperative outcomes. In surgical, experimental, chronic, and neuropathic pain models, females have been reported to have more pain than males. This review focuses on literature evidence of differences in pain relief due to multiple genetic variations and gender of the patient.

Keywords: pain, analgesia, pain genomics, pharmacogenomics, pharmacokinetics, pharmacodynamics

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