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Gender differences in the association between C-reactive protein, lung function impairment, and COPD

Authors Inga Sif Ólafsdóttir, Thórarinn Gíslason, Bjarni Thjóðleifsson, Ísleifur Ólafsson, Davíd Gíslason, et al

Published 15 January 2008 Volume 2007:2(4) Pages 635—642

Inga Sif Ólafsdóttir1, Thórarinn Gíslason2, Bjarni Thjóðleifsson3, Ísleifur Ólafsson4, Davíd Gíslason2, Rain Jõgi5, Christer Janson1

1Department of Medical Sciences: Respiratory Medicine and Allergology, Uppsala University, Uppsala, Sweden; 2Department of Allergy, Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland; 3Department of Gastroenterology, Landspitali University Hospital, Reykjavik, Iceland; 4Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland; 5Lung Clinic of Tartu University Hospital, Tartu, Estonia

Abstract: Individuals with COPD have systemic inflammation that can be assessed by measuring C-reactive protein (CRP). In this paper we evaluated whether CRP is related to COPD, lung function and rate of lung function decline. We included 1237 randomly selected subjects (mean age 42, range 28–56 years) from three centers in the European Community Respiratory Health Survey: Reykjavik, Uppsala and Tartu. CRP was measured at the end of the follow-up (mean 8.3 years) and the values were divided into 4 quartiles. Fifty-three non-asthmatic subjects fulfilled spirometric criteria for COPD (FEV1/FVC < 70%). COPD occurred more often in the 4th CRP quartile (OR (95% CI) 3.21 (1.13–9.08)) after adjustment for age, gender, body weight and smoking. High CRP levels were related to lower FEV1 values in both men (−437 (−596, −279) mL) and women (−144 (−243, −44) mL). The negative association between CRP and FEV1 was significantly larger in men than women (p = 0.04). The decline in FEV1 was larger (16 (5, 27) mL) in men with high CRP levels whereas no significant association between CRP and FEV1 decline was found in women. Higher CRP values are significantly associated with COPD and lower lung function in men and women. In men higher CRP values are related to a larger decline in FEV1.

Keywords: C-reactive protein, COPD, body mass index, spirometry, ECRHS

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